cover image: The Indian Medical Gazette. a Monthly Journal of Medicine  Surgery  Public Health  and General Medical Intelligence  Indian and European. May 1947

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The Indian Medical Gazette. a Monthly Journal of Medicine Surgery Public Health and General Medical Intelligence Indian and European. May 1947

1947

From the third day onwards the action of the three regimes seemed to depend on the strength of their dosage being comparatively slow with A rather quick with C and intemediate with B. In the majority of the cases the parasites had disappeared from the blood within three days-82 per cent in A 88 per cent in B and 93 per cent in C. The corresponding figures as regards temperature were 73 88 a [...] In the majority of the cases treated the asexual forms of the malaria parasite diappeared from the peripheral blood in one to three days after administration of paludrine and remained free from asexual forms unless a relapse occurred. [...] In contrast to the rapid disappearance of asexual parasites from the peripheral blood that generally followed the administration of paludrine it was observed that the gametocytes of all the three species of malaria parasites persisted in the peripheral blood for prolonged periods ranging from 4 to 20 days. [...] Though asked by the manufacturers to copare this new drug with other antimalarials in the clinic it seemed to us from a study of the laboratory protocols given to us that if this compound showed in man the low toxicity the high therapeutic value the rapid establishment of a high plasma level and the slow excretion observed in laboratory animals it might at last be a real answer to the [...] The permanent clearance of the peripheral blood—excepting crescents which happened to be present at the time—ranged from a few hours to a maximum of 46 hours in B. T. and 40 hours in M. T. The average clearance time was r hours for B. T. and 25 for M. T. cases.
technology medicine science
Pages
85
Published in
India
SARF Document ID
sarf.120338
Segment Pages Author Actions
Frontmatter
i-ii S.D.S. Greval view
Clinical Trials of Paludrine
247-253 R.N. Chaudhuri, M.N. Chaudhuri view
Clinical Trial of Paludrine in Malaria
253-255 J.G. Parekh, B.P. Boghani view
Preliminary Report on a New Synthetic Antimalarial
255-257 A.T.W. Simeons, K.G. Chhatre view
A Clinical Study on Paludrine
257-260 M.N. De, Pramatha Dutta view
Investigation on a Case of Feminism
260-263 P. De, E.G. Montgomery view
Treatment of Osteoarthritis with Intra-Articular Injections of Lactic Acid
264-265 B. Ramamurthi view
Serological Technique (Contd.)
265-269 S.D.S. Greval view
A Typical Case of Iso-Immunization Against the Rhesus Factor
269-272 K.S. Ranganathan view
A Mirror of Hospital Practice
272-276 S.D.S. Greval view
Therapeutic Notes
276-278 S.D.S. Greval view
Indian Medical Gazette
279-281 S.D.S. Greval view
History of Kala-Azar in India
281-286 P.C. Gupta view
Medical News
286-292 S.D.S. Greval view
Public Health Section
293-293 S.D.S. Greval view
The Indian Medical Gazette Fifty Years Ago
294-296 S.D.S. Greval view
Current Topics Etc
296-304 S.D.S. Greval view
Reviews
304-306 S.D.S. Greval view
Books Received
306-306 S.D.S. Greval view
Abstracts from Reports
306-307 S.D.S. Greval view
Correspondence
307-307 P.V. Karamchandani view
Any Questions
307-309 S.D.S. Greval view
Service Notes
309-310 S.D.S. Greval view

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